C4859
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C4859
Sigma
Cycloheximide solution
Ready-Made Solution, microbial, 100 mg/mL in DMSO, 0.2 μm filtered
| Synonym: | CHX |
| CAS Number: | 66-81-9 |
| Linear Formula: | C15H23NO4 |
| Molecular Weight: | 281.35 |
| MDL number: | MFCD00082346 |
| PubChem Substance ID: | 24892732 |
Description
| Biochem/physiol Actions | Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. |
| Specificity | Tested for cell growth arrest, selection of cycloheximide resistant yeast, apoptosis induction, and facilitation of apoptosis induction by FasL. |
Properties
| biological source | microbial |
| sterility | 0.2 μm filtered |
| concentration | 100 mg/mL in DMSO |
| Gene Information | human ... FKBP1A(2280), PIN1(5300) |
| storage temp. | 2-8°C |
Safety
| Hazard Codes | T+,N |
| Risk Statements | 61-28-52/53-68 |
| Safety Statements | 53-45 |
| RIDADR | UN 2810 6.1/PG 2 |
| WGK Germany | 3 |
| Flash Point(F) | 189 °F |
| Flash Point(C) | 87 °C |
References
| reference | Kominek, L.A. Antimicrob. Agents Chemother. 7, 856, (1975) Abstract |
| Smith, A.D., et al. Dictionary of Microbiology and Molecular Biology, (1997) | |
| Lennette, E.H., et al. Manual of Clinical Microbiology 4th ed., Washington D.C. , (1985), 500 | |
| Lin, W.W., and Hsu, Y.W. Cell. Signal. 12, 457, (2000) Abstract | |
| Mizel, S.B., and Mizel, D. J. Immunol. 126, 834, (1981) Abstract | |
| Ma, Q., et al. J. Biol. Chem. 275, 12676, (2000) Abstract | |
| Clemens, M.J., et al. Oncogene 17, 2921, (1998) Abstract | |
| Fulda, S. Cancer Res. 60, 3947, (2000) Abstract |
